Royal Air Force Typhoon FGR4s have joined forces with French warplanes in a combined operation against an subterranean weapons facility in Syria operated by the IS group, as stated by the UK's MoD.
The location, identified by intelligence, was thought to be containing munitions and bombs, the statement said, and was situated in mountainous terrain just above the ancient city of Palmyra in the heart of Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to strike a series of approach shafts leading to the depot... preliminary assessments suggest the strike was effective," officials stated.
There was no evidence of any civilian casualties in the strike conducted Saturday night and each participating jet returned safely, the defence officials confirmed.
The British jets were assisted by a Voyager tanker plane.
Daesh - also known as Daesh - established militant control over significant areas in Iraq and Syria until 2019.
"This operation demonstrates British leadership, and determination to operate in unison with allied nations, to stamp out any resurgence of IS and their violent and radical beliefs in the region," the British Defence Secretary John Healey remarked.
UK warplanes have conducted overwatch operations over Syria to "prevent any efforts to regroup" of IS after its routing at the Baghuz confrontation in 2019, the ministry said.
"I must thank the personnel of our armed forces who took part in this mission for their skill and their courage," the Defence Secretary commented. "Including them were thousands of British personnel on duty over the holidays. This action, to take out terrorist threats who pose a risk to our safety, shows how our armed forces are prepared to act, throughout the year, ensuring Britain's security domestically and strong abroad."
In December, the US military executed what it described as a "massive strike" against Daesh sites in Syria, following an assault killed two American soldiers and a civilian interpreter in Palmyra.
The UN estimates Daesh still boasts between 5,000 and 7,000 fighters in both countries.